PNU112455A (hydrochloride)
PNU112455A hydrochloride is an ATP-competitive CDK2 and CDK5 inhibitor. PNU112455A hydrochloride binds to the ATP site of CDK2 and CDK5 with Kms of 3.6 and 3.2 μM, respectively[1].
Product Specifications
CAS Number
21886-12-4
UNSPSC
12352005
Hazard Statement
H302-H315-H319-H335
Target
CDK
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/pnu112455a-hydrochloride.html
Purity
99.56
Solubility
DMSO : 125 mg/mL (ultrasonic) |H2O : 20 mg/mL (ultrasonic)
Smiles
O=S(C1=CC=C(NC2=NC=NC(N)=C2)C=C1)(N)=O.[H]Cl
Molecular Formula
C10H12ClN5O2S
Molecular Weight
301.75
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
References & Citations
[1]Clare PM, et al. The cyclin-dependent kinases cdk2 and cdk5 act by a random, anticooperative kinetic mechanism. J Biol Chem. 2001 Dec 21;276 (51) :48292-9.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CDK2; CDK5
Available Sizes
Frequently Asked Questions
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