PNU112455A (hydrochloride)

PNU112455A hydrochloride is an ATP-competitive CDK2 and CDK5 inhibitor. PNU112455A hydrochloride binds to the ATP site of CDK2 and CDK5 with Kms of 3.6 and 3.2 μM, respectively[1].

Product Specifications

CAS Number

[21886-12-4]

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

CDK

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/pnu112455a-hydrochloride.html

Purity

99.56

Solubility

DMSO : 125 mg/mL (ultrasonic) |H2O : 20 mg/mL (ultrasonic)

Smiles

O=S(C1=CC=C(NC2=NC=NC(N)=C2)C=C1)(N)=O.[H]Cl

Molecular Formula

C10H12ClN5O2S

Molecular Weight

301.75

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

References & Citations

[1]Clare PM, et al. The cyclin-dependent kinases cdk2 and cdk5 act by a random, anticooperative kinetic mechanism. J Biol Chem. 2001 Dec 21;276 (51) :48292-9.