Welcome to GenPrice! Check out our latest updates.

Shopping Cart (0)

Your cart is empty

Add some products to get started!

GN44028

GN44028 is a potent and orally active hypoxia inducible factor (HIF) -1α inhibitor, with an IC50 of 14 nM. GN44028 inhibits hypoxia-induced HIF-1α transcriptional activity without suppressing HIF-1α mRNA expression, HIF-1α protein accumulation, or HIF-1α/HIF-1β heterodimerization. GN44028 can be used in the research of cancers[1][3].

Product Specifications

CAS Number

1421448-26-1

UNSPSC

12352005

Target

HIF/HIF Prolyl-Hydroxylase

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Neuroscience-Neurodegeneration

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/gn-44028.html

Concentration

10mM

Purity

99.60

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

C1(NC2=CC=C(OCCO3)C3=C2)=NNC4=C1CC5=CC=CC=C45

Molecular Formula

C18H15N3O2

Molecular Weight

305.33

References & Citations

[1]Minegishi H, et al. Discovery of Indenopyrazoles as a New Class of Hypoxia Inducible Factor (HIF) -1 Inhibitors. ACS Med Chem Lett. 2013 Jan 27;4 (2) :297-301.|[2]Changfu Liu, et al. Tumor-associated macrophage-derived transforming growth factor-β promotes colorectal cancer progression through HIF1-TRIB3 signaling. Cancer Sci. 2021 Oct;112 (10) :4198-4207. |[3]Xiaoqing Fan, et al. Heterogeneity of subsets in glioblastoma mediated by Smad3 palmitoylation. Oncogenesis. 2021 Oct 27;10 (10) :72.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Frequently Asked Questions

More Discoveries

Explore Other Products

Browse additional items from our catalog

DCP1B Mouse Monoclonal Antibody (Biotin conjugated) [Clone ID: OTI1C5]
TA809929AM 100 µL

DCP1B Mouse Monoclonal Antibody (Biotin conjugated) [Clone ID: OTI1C5]

Sign In for Pricing
View Details
Gp100 / Melanosome / PMEL17 / SILV (Melanoma Marker) (PMEL/2038), CF594 conjugate, 0.1mg/mL
BNC942038-100 1x 100 µL

Gp100 / Melanosome / PMEL17 / SILV (Melanoma Marker) (PMEL/2038), CF594 conjugate, 0.1mg/mL

Sign In for Pricing
View Details
Tissue Genomic DNA, Lung
CD565236 5 µg

Tissue Genomic DNA, Lung

Sign In for Pricing
View Details
Ccnl2 Mouse Gene Knockout Kit (CRISPR)
KN502824 1 Kit

Ccnl2 Mouse Gene Knockout Kit (CRISPR)

Sign In for Pricing
View Details
FMPEP-d2
TRC-F193441-10MG 10 mg

FMPEP-d2

Sign In for Pricing
View Details
Sodium Phosphate Monobasic Monohydrate
TRC-S667045-5G 5 g

Sodium Phosphate Monobasic Monohydrate

Sign In for Pricing
View Details