GN44028

GN44028 is a potent and orally active hypoxia inducible factor (HIF) -1α inhibitor, with an IC50 of 14 nM. GN44028 inhibits hypoxia-induced HIF-1α transcriptional activity without suppressing HIF-1α mRNA expression, HIF-1α protein accumulation, or HIF-1α/HIF-1β heterodimerization. GN44028 can be used in the research of cancers[1][3].

Product Specifications

CAS Number

[1421448-26-1]

UNSPSC

12352005

Target

HIF/HIF Prolyl-Hydroxylase

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Neuroscience-Neurodegeneration

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/gn-44028.html

Concentration

10mM

Purity

99.60

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

C1(NC2=CC=C(OCCO3)C3=C2)=NNC4=C1CC5=CC=CC=C45

Molecular Formula

C18H15N3O2

Molecular Weight

305.33

References & Citations

[1]Minegishi H, et al. Discovery of Indenopyrazoles as a New Class of Hypoxia Inducible Factor (HIF) -1 Inhibitors. ACS Med Chem Lett. 2013 Jan 27;4 (2) :297-301.|[2]Changfu Liu, et al. Tumor-associated macrophage-derived transforming growth factor-β promotes colorectal cancer progression through HIF1-TRIB3 signaling. Cancer Sci. 2021 Oct;112 (10) :4198-4207. |[3]Xiaoqing Fan, et al. Heterogeneity of subsets in glioblastoma mediated by Smad3 palmitoylation. Oncogenesis. 2021 Oct 27;10 (10) :72.