TBTC
TBTC is a selective agonist with the activity of improving behavioral deficits in Alzheimer's disease model mice. TBTC can effectively activate the heterodimerization of RXRα with LXRα or PPARγ. TBTC stimulates the expression of apoE, ABCA1, and ABCG1 genes and reduces Aβ content in cells and animal models[1].
Product Specifications
CAS Number
[213192-26-8]
UNSPSC
12352005
Hazard Statement
H315-H319-H320
Target
RAR/RXR
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/tbtc.html
Smiles
O=C(OC)C1=C(SC2=C1CCC(C2)C(C)(C)C)N
Molecular Formula
C14H21NO2S
Molecular Weight
267.39
Precautions
P264-P280-P302+P352-P305+P351+P338-P362
References & Citations
[1]Small molecule TBTC as a new selective retinoid X receptor α agonist improves behavioral deficit in Alzheimer's disease model mice
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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