DU-14

DU-14 is a potent steroid sulfatase inhibitor with an IC50 of 55.8 nM. DU-14 inhibits the MCF-7 cell proliferation (IC50 = 38.7 nM) . DU-14 has neuroprotective effects against neurotoxic Aβ, suggesting that up-regulation of endogenous DHEAS by DU-14 could be beneficial to the alleviation of Aβ-induced impairments in spatial memory and synaptic plasticity[1][2][3].

Product Specifications

CAS Number

[186303-55-9]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Steroid Sulfatase

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/du-14.html

Purity

99.18

Solubility

DMSO : 125 mg/mL (ultrasonic)

Smiles

CCCCCCCCCCCCCC(NCCC1=CC=C(C=C1)OS(N)(=O)=O)=O

Molecular Formula

C22H38N2O4S

Molecular Weight

426.61

Precautions

H302, H315, H319, H335

References & Citations

[1]Selcer KW, et al. Inhibition of estrone sulfatase and proliferation of human breast cancer cells by nonsteroidal (p-O-sulfamoyl) -N-alkanoyl tyramines. Cancer Res. 1997 Feb 15;57 (4) :702-7. |[2]Li PK, et al. Memory enhancement mediated by the steroid sulfatase inhibitor (p-O-sulfamoyl) -N-tetradecanoyl tyramine. Life Sci. 1997;60 (3) :PL45-51. |[3]Yue XH, et al. Steroid sulfatase inhibitor DU-14 protects spatial memory and synaptic plasticity from disruption by amyloid β protein in male rats. Horm Behav. 2016 Jul;83:83-92.