C-Myb (Acetyl Lys480) rabbit pAb
Domain: Comprised of 3 domains; an N-terminal DNA-binding domain, a centrally located transcriptional activation domain and a C-terminal domain involved in transcriptional repression. function: Transcriptional activator; DNA-binding protein that specifically recognize the sequence 5'-YAAC[GT]G-3'. Plays an important role in the control of proliferation and differentiation of hematopoietic progenitor cells. PTM: Phosphorylated by NLK on multiple sites, which induces proteasomal degradation. PTM: Ubiquitinated; mediated by SIAH1 and leading to its subsequent proteasomal degradation. similarity: Contains 3 HTH myb-type DNA-binding domains. subunit: Binds MYBBP1A. Interacts with HIPK2, MAF and NLK.
Product Specifications
Background
Synonyms
Transcriptional activator Myb (Proto-oncogene c-Myb)
Gene ID
4602
UniProt
P10242
Cellular Locus
Nucleus.
Host
Rabbit
Species Reactivity
Human,Mouse
Reactivity
Human; Mouse
Immunogen
Synthesized peptide derived from human c-Myb (Acetyl Lys480)
Clonality
Polyclonal
Isotype
IgG
Source
Rabbit
Applications
WB, ELISA
Validated Applications
WB,ELISA
Stability
-20°C/1 year
Concentration
1 mg/mL
Dilution
WB 1:1000-2000 ELISA 1:5000-20000
Molecular Weight
70kD
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles.
Product Datasheet
https://www.elkbiotech.com/upload/file/Antibodies/pAb/ES20115-1.pdf
Observed Molecular Weight
70 kD
Subcellular Location
Nucleus .
Other Product Names
Transcriptional activator Myb (Proto-oncogene c-Myb)
Gene ID (Human)
4602
SwissProt (Human)
P10242
Available Sizes
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