1,5-Isoquinolinediol
1,5-Isoquinolinediol is a potent PARP inhibitor, with an IC50 of 0.18-0.37 μM. 1,5-Isoquinolinediol attenuates diabetes-induced NADPH oxidase-derived oxidative stress in retina[1][2].
Product Specifications
CAS Number
[5154-02-9]
UNSPSC
12352005
Hazard Statement
H315, H319, H335
Target
PARP
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Epigenetics
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/1-5-isoquinolinediol.html
Purity
99.14
Solubility
DMSO : 37.04 mg/mL (ultrasonic)
Smiles
O=C1NC=CC2=C1C=CC=C2O
Molecular Formula
C9H7NO2
Molecular Weight
161.16
Precautions
H315, H319, H335
References & Citations
[1]Crockett SL, et al. Role of dopamine and selective dopamine receptor agonists on mouse ductus arteriosus tone and responsiveness. Pediatr Res. 2019 Dec 9.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PARP
Available Sizes
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