1,5-Isoquinolinediol

1,5-Isoquinolinediol is a potent PARP inhibitor, with an IC50 of 0.18-0.37 μM. 1,5-Isoquinolinediol attenuates diabetes-induced NADPH oxidase-derived oxidative stress in retina[1][2].

Product Specifications

CAS Number

[5154-02-9]

UNSPSC

12352005

Hazard Statement

H315, H319, H335

Target

PARP

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Epigenetics

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/1-5-isoquinolinediol.html

Purity

99.14

Solubility

DMSO : 37.04 mg/mL (ultrasonic)

Smiles

O=C1NC=CC2=C1C=CC=C2O

Molecular Formula

C9H7NO2

Molecular Weight

161.16

Precautions

H315, H319, H335

References & Citations

[1]Crockett SL, et al. Role of dopamine and selective dopamine receptor agonists on mouse ductus arteriosus tone and responsiveness. Pediatr Res. 2019 Dec 9.