Bepafant
Bepafant (Web2170) is a platelet-activating factor (PAF) antagonist that protects against anaphylactic lethality in active and passive anaphylaxis models in mice and guinea pigs in a dose-dependent manner and attenuates bronchoconstriction and blood pressure changes in anaphylaxis.
Product Specifications
CAS Number
[114776-28-2]
Product Name Alternative
Web2170
UNSPSC
12352005
Target
Platelet-activating Factor Receptor (PAFR)
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
Neuroscience-Neuromodulation
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/bepafant.html
Smiles
O=C(C1CC2=C(C1)C(C(C3=C(Cl)C=CC=C3)=NCC4=NN=C(C)N45)=C5S2)N6CCOCC6
Molecular Formula
C23H22ClN5O2S
Molecular Weight
467.97
References & Citations
[1]Effect of the hetrazepinoic platelet-activating factor antagonist Bepafant (WEB 2170) in models of active and passive anaphylaxis in mice and guinea pigs|[2]Compounds biologically similar to platelet activating factor are present in stored blood components
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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