Bepafant

Bepafant (Web2170) is a platelet-activating factor (PAF) antagonist that protects against anaphylactic lethality in active and passive anaphylaxis models in mice and guinea pigs in a dose-dependent manner and attenuates bronchoconstriction and blood pressure changes in anaphylaxis.

Product Specifications

CAS Number

[114776-28-2]

Product Name Alternative

Web2170

UNSPSC

12352005

Target

Platelet-activating Factor Receptor (PAFR)

Type

Reference compound

Related Pathways

GPCR/G Protein

Applications

Neuroscience-Neuromodulation

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/bepafant.html

Smiles

O=C(C1CC2=C(C1)C(C(C3=C(Cl)C=CC=C3)=NCC4=NN=C(C)N45)=C5S2)N6CCOCC6

Molecular Formula

C23H22ClN5O2S

Molecular Weight

467.97

References & Citations

[1]Effect of the hetrazepinoic platelet-activating factor antagonist Bepafant (WEB 2170) in models of active and passive anaphylaxis in mice and guinea pigs|[2]Compounds biologically similar to platelet activating factor are present in stored blood components