MLK3 (Phospho Thr277+Ser281) rabbit pAb
The protein encoded by this gene is a member of the serine/threonine kinase family. This kinase contains a SH3 domain and a leucine zipper-basic motif. This kinase preferentially activates MAPK8/JNK kinase, and functions as a positive regulator of JNK signaling pathway. This kinase can directly phosphorylate, and activates IkappaB kinase alpha and beta, and is found to be involved in the transcription activity of NF-kappaB mediated by Rho family GTPases and CDC42. [provided by RefSeq, Jul 2008],
Product Specifications
Background
UniProt
Q16584
Swiss Prot
Q16584
Reactivity
Human; Mouse; Rat
Immunogen
Synthesized peptide derived from human MLK3 (Phospho Thr277+Ser281)
Clonality
Polyclonal
Source
Rabbit
Applications
WB; ELISA; IHC
Concentration
1 mg/ml
Dilution
WB 1:500-2000; IHC-p 1:50-300; ELISA 2000-20000
Storage Conditions
-20°C/1 year
Fragment
IgG
Subcellular Location
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Location is cell cycle dependent.
Other Product Names
Mitogen-activated protein kinase kinase kinase 11 (EC 2.7.11.25; Mixed lineage kinase 3; Src-homology 3 domain-containing proline-rich kinase)
Gene ID (Human)
4296
Available Sizes
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