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Mitraphylline (Standard)

Mitraphylline (Standard) is the analytical standard of Mitraphylline. This product is intended for research and analytical applications. Mitraphylline is the major pentacyclic oxindolic alkaloid presented in Uncaria tomentosa. Mitraphylline inhibits lipopolysaccharide-mediated activation of primary human neutrophils. Mitraphylline exhibits antiproliferative activity in human glioma and neuroblastoma cell lines. Mitraphylline can inhibit interleukin release in vivo[1][2][3].

Product Specifications

CAS Number

509-80-8

UNSPSC

12352005

Target

Interleukin Related; NF-κB; Reference Standards

Type

Reference Standards

Related Pathways

Immunology/Inflammation; NF-κB; Others

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/mitraphylline-standard.html

Smiles

O=C1NC2=C([C@@]13CCN4C[C@@]5([C@@H](OC=C([C@]5(C[C@]43[H])[H])C(OC)=O)C)[H])C=CC=C2

Molecular Formula

C21H24N2O4

Molecular Weight

368.43

References & Citations

[1]Montserrat-de la Paz S, et al. Mitraphylline inhibits lipopolysaccharide-mediated activation of primary human neutrophils. Phytomedicine. 2016 Feb 15;23 (2) :141-8.|[2]Rojas-Duran, R., et al., (2012) . Anti-inflammatory activity of Mitraphylline isolated from Uncaria tomentosa bark. Journal of ethnopharmacology, 143 (3), 801–804.|[3]García Prado, E., et al., (2007) . Antiproliferative effects of mitraphylline, a pentacyclic oxindole alkaloid of Uncaria tomentosa on human glioma and neuroblastoma cell lines. Phytomedicine : international journal of phytotherapy and phytopharmacology, 14 (4), 280–284.

Shipping Conditions

Room temperature

Scientific Category

Reference Standards

Frequently Asked Questions

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