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AJ-76 (hydrochloride)

AJ-76 hydrochloride ((+) -AJ 76 hydrochloride) is an antagonist of dopamine autoreceptor with pKi values of 6.95, 6.67, 6.37, 6.21 and 6.07 for hD3, hD4, hD2S, hD2L and rD2 receptors, respectively.

Product Specifications

CAS Number

85378-82-1

Product Name Alternative

(+) -AJ 76 (hydrochloride) ; (1S,2R) -AJ 76 (hydrochloride)

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Dopamine Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/aj-76-hydrochloride.html

Purity

98.55

Solubility

DMSO : 12.5 mg/mL (ultrasonic; warming; heat to 60°C) |Methanol : 25 mg/mL (ultrasonic)

Smiles

CCCN[C@H]1[C@@H](C)C2=C(C(OC)=CC=C2)CC1.Cl

Molecular Formula

C15H24ClNO

Molecular Weight

269.82

Precautions

H302, H315, H319, H335

References & Citations

[1]Kullingsjö H, et al. Effects of repeated administration of the preferential dopamine autoreceptor antagonist, (+) -AJ76, on locomotor activity and brain DA metabolism in the rat. Eur J Pharmacol. 1991 Dec 3;205 (3) :241-6.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, sealed storage, away from moisture)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Frequently Asked Questions

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