Deoxycholic acid

Deoxycholic acid (cholanoic acid), a bile acid, is a by-product of intestinal metabolism, that activates the G protein-coupled bile acid receptorTGR5[1][2].

Product Specifications

CAS Number

[83-44-3]

Product Name Alternative

Cholanoic acid; Desoxycholic acid

UNSPSC

12352211

Hazard Statement

H302, H315, H319, H335

Target

Endogenous Metabolite; G protein-coupled Bile Acid Receptor 1

Type

Natural Products

Related Pathways

GPCR/G Protein; Metabolic Enzyme/Protease

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/Deoxycholic_acid.html

Purity

99.95

Solubility

DMSO : ≥ 100 mg/mL|H2O : < 0.1 mg/mL (ultrasonic; warming; heat to 80°C)

Smiles

C[C@@]1([C@@]2([H])[C@H](C)CCC(O)=O)[C@](CC2)([H])[C@@](CC[C@@]3([H])[C@@]4(CC[C@@H](O)C3)C)([H])[C@]4([H])C[C@@H]1O

Molecular Formula

C24H40O4

Molecular Weight

392.57

Precautions

H302, H315, H319, H335

References & Citations

[1]Somm E, et al. β-Klotho deficiency protects against obesity through a crosstalk between liver, microbiota, and brown adipose tissue. JCI Insight. 2017 Apr 20;2 (8) . pii: 91809.|[2]Wang X, et al. Acidified bile acids enhance tumor progression and telomerase activity of gastric cancer in micedependent on c-Myc expression. Cancer Med. 2017 Apr;6 (4) :788-797.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Natural Products

Clinical Information

Launched

Isoform

Human Endogenous Metabolite; Microbial Metabolite

Citation 01

Adv Sci (Weinh) . 2025 Feb 3:e2411719.|Aquaculture. 2023 Sep 18, 740123.|Biomedicines. 2025 Apr 4;13 (4) :874.|Cancer Cell Int. 2019 Jan 31:19:24.|Cell Death Discov. 2020 Jul 6;6:56.|Cell Host Microbe. 2025 Aug 19:S1931-3128 (25) 00291-4.|Cell Host Microbe. 2025 Jun 11;33 (6) :915-931.e9.|Cell Res. 2019 Mar;29 (3) :193-205. |Chin Med J (Engl) . 2025 Jun 16.|Drug Metab Dispos. 2021 May;49 (5) :369-378.|Gut Microbes. 2025 Dec 31;17 (1) :2582944.|Int J Biol Macromol. 2024 May;266 (Pt 1) :130939.|J Invest Dermatol. 2022 May;142 (5) :1381-1390.e11.|J Pharm Biomed Anal. 2025 Jul 15:259:116760.|Laurea Magistrale in Biomedical Engineering, Politecnico di Milano. 2019 Jun.|Microb Pathog. 2026 Jan:210:108187.|Microbiome. 2019 Mar 20;7 (1) :43. |Nat Cardiovasc Res. 2025 May;4 (5) :584-601.|Nature. 2025 Jul;643 (8070) :192-200.|R Soc Open Sci. 2020 Jul 8;7 (7) :200635.|Cell Rep. 2025 Sep 17;44 (10) :116306.|J Transl Med. 2024 Dec 20;22 (1) :1124.|Nat Cell Biol. 2018 Oct;20 (10) :1145-1158.