6-Maleimidohexanoic acid N-hydroxysuccinimide ester
6-Maleimidohexanoic acid N-hydroxysuccinimide ester (EMCS) is a heterobifunctional cross-linking reagent. EMCS is used as a unique and useful reagent for preparation of hapten conjugate and enzyme immunoconjugates[1].
Product Specifications
CAS Number
[55750-63-5]
Product Name Alternative
EMCS
UNSPSC
12352203
Hazard Statement
H351
Target
ADC Linker
Type
ADC Related
Related Pathways
Antibody-drug Conjugate/ADC Related
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/6-maleimidohexanoic-acid-n-hydroxysuccinimide-ester.html
Purity
99.98
Solubility
DMSO : ≥ 100 mg/mL
Smiles
O=C(C=C1)N(CCCCCC(ON2C(CCC2=O)=O)=O)C1=O
Molecular Formula
C14H16N2O6
Molecular Weight
308.29
Precautions
H351
References & Citations
[1]Shinya Kida, et al. Studies on heterobifunctional cross-linking reagents, 6-maleimidohexanoic acid active esters. Chem Pharm Bull (Tokyo) . 2007 Apr;55 (4) :685-7.|[2]Shinya Kida, et al. Evaluation of synthetic cell-penetrating peptides, Pro-rich peptide and octaargine derivatives, as adenovirus vector carrier. Protein Pept Lett. 2010 Feb;17 (2) :164-7.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture and light)
Scientific Category
ADC Related
Clinical Information
No Development Reported
Isoform
Non-cleavable Linker
Available Sizes
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