L2H2-6OTD
Product Specifications
UNSPSC Description
L2H2-6OTD, containing one to four G-quadruplex binding loops, is a telomeric inhibitor analogue. l2H2-6OTD has telomerase inhibitory activity with an IC50 value of 15 nM[1].
Target Antigen
ADC Cytotoxin; Telomerase
Type
Reference compound
Related Pathways
Antibody-drug Conjugate/ADC Related;Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/l2h2-6otd.html
Solubility
10 mM in DMSO
Smiles
NCCCC[C@H](NC(C1=COC(C2=COC3=N2)=N1)=O)C4=NC(C5=NC(C6=NC(C(N[C@H](C7=NC3=CO7)CCCCN)=O)=CO6)=CO5)=CO4
Molecular Weight
658.62
References & Citations
[1]Keisuke Iida, et al. Evaluation of the interaction between long telomeric DNA and macrocyclic hexaoxazole (6OTD) dimer of a G-quadruplex ligand. Molecules. 2013 Apr 12;18(4):4328-41.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-148200/L2H2-6OTD-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-148200/
Clinical Information
No Development Reported
CAS Number
1016263-75-4
Available Sizes
Curated Selection
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