L2H2-6OTD
L2H2-6OTD, containing one to four G-quadruplex binding loops, is a telomeric inhibitor analogue. l2H2-6OTD has telomerase inhibitory activity with an IC50 value of 15 nM[1].
Product Specifications
CAS Number
1016263-75-4
UNSPSC
12352005
Target
ADC Payload; Telomerase
Type
Reference compound
Related Pathways
Antibody-drug Conjugate/ADC Related; Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/l2h2-6otd.html
Solubility
10 mM in DMSO
Smiles
NCCCC[C@H](NC(C1=COC(C2=COC3=N2)=N1)=O)C4=NC(C5=NC(C6=NC(C(N[C@H](C7=NC3=CO7)CCCCN)=O)=CO6)=CO5)=CO4
Molecular Formula
C30H30N10O8
Molecular Weight
658.62
References & Citations
[1]Keisuke Iida, et al. Evaluation of the interaction between long telomeric DNA and macrocyclic hexaoxazole (6OTD) dimer of a G-quadruplex ligand. Molecules. 2013 Apr 12;18 (4) :4328-41.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
LH20031V 100 µg
Cytochrome p450 2C19 (CYP2C19) (NM_000769) Human Over-expression Lysate
Sign In for Pricing
View Details GTR15226680 1 Vial
Lentiviral mouse Sertad1 shRNA (UAS) - Lentiviral mouse Sertad1 shRNA (UAS, RFP) (100)
Sign In for Pricing
View Details MBS1415200-01 0.02 mg (E-Coli)
Recombinant Porphyromonas gingivalis Thymidylate synthase (thyA)
Sign In for Pricing
View Details