L2H2-6OTD
L2H2-6OTD, containing one to four G-quadruplex binding loops, is a telomeric inhibitor analogue. l2H2-6OTD has telomerase inhibitory activity with an IC50 value of 15 nM[1].
Product Specifications
CAS Number
1016263-75-4
UNSPSC
12352005
Target
ADC Payload; Telomerase
Type
Reference compound
Related Pathways
Antibody-drug Conjugate/ADC Related; Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/l2h2-6otd.html
Solubility
10 mM in DMSO
Smiles
NCCCC[C@H](NC(C1=COC(C2=COC3=N2)=N1)=O)C4=NC(C5=NC(C6=NC(C(N[C@H](C7=NC3=CO7)CCCCN)=O)=CO6)=CO5)=CO4
Molecular Formula
C30H30N10O8
Molecular Weight
658.62
References & Citations
[1]Keisuke Iida, et al. Evaluation of the interaction between long telomeric DNA and macrocyclic hexaoxazole (6OTD) dimer of a G-quadruplex ligand. Molecules. 2013 Apr 12;18 (4) :4328-41.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
![SARS-CoV-2 N Protein Mouse Monoclonal Antibody [Clone ID: LBI4H5]](https://cdn.genprice.uk/genprice/uk/genprice2.webp)
AMM21575V 100 µL
SARS-CoV-2 N Protein Mouse Monoclonal Antibody [Clone ID: LBI4H5]
Sign In for Pricing
View Details 
MBS1576687-01 0.1 mg
Recombinant Human MED15 Protein, N-His-SUMO & C-Strep
Sign In for Pricing
View Details MBS1576687-02 1 mg
Recombinant Human MED15 Protein, N-His-SUMO & C-Strep
Sign In for Pricing
View Details MBS1576687-03 5x 1 mg
Recombinant Human MED15 Protein, N-His-SUMO & C-Strep
Sign In for Pricing
View Details