ZXH-8-004
ZXH-8-004 (2-12-2-deg) is a potent DENV E PROTAC degrader with an DC50 value of 0.21 µM. ZXH-8-004 shows exhibit antiviral potencies (Blue: E3 ligase (HY-103596), Black: linker (HY-42149) ; Pink: DENV E ligand (HY-161807) ) [1].
Product Specifications
UNSPSC
12352005
Target
Dengue Virus; PROTACs
Type
Reference compound
Related Pathways
Anti-infection; PROTAC
Applications
Cancer-programmed cell death
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/zxh-8-004.html
Smiles
FC(F)(F)OC1=CC=C(NC2=CC=NC(NC3=CC=C(C(NCCOCCOCCOC4=C5C(C(N(C6CCC(NC6=O)=O)C5=O)=O)=CC=C4)=O)C=C3OC(F)(F)F)=N2)C=C1
Molecular Formula
C38H33F6N7O10
Molecular Weight
861.70
References & Citations
[1]Liu HY, et al. Broad-spectrum activity against mosquito-borne flaviviruses achieved by a targeted protein degradation mechanism. Nat Commun. 2024 Jun 19;15 (1) :5179.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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