ZXH-8-004

ZXH-8-004 (2-12-2-deg) is a potent DENV E PROTAC degrader with an DC50 value of 0.21 µM. ZXH-8-004 shows exhibit antiviral potencies (Blue: E3 ligase (HY-103596), Black: linker (HY-42149) ; Pink: DENV E ligand (HY-161807) ) [1].

Product Specifications

UNSPSC

12352005

Target

Dengue Virus; PROTACs

Type

Reference compound

Related Pathways

Anti-infection; PROTAC

Applications

Cancer-programmed cell death

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/zxh-8-004.html

Smiles

FC(F)(F)OC1=CC=C(NC2=CC=NC(NC3=CC=C(C(NCCOCCOCCOC4=C5C(C(N(C6CCC(NC6=O)=O)C5=O)=O)=CC=C4)=O)C=C3OC(F)(F)F)=N2)C=C1

Molecular Formula

C38H33F6N7O10

Molecular Weight

861.70

References & Citations

[1]Liu HY, et al. Broad-spectrum activity against mosquito-borne flaviviruses achieved by a targeted protein degradation mechanism. Nat Commun. 2024 Jun 19;15 (1) :5179.