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(R) -Funapide

(R) -Funapide ((R) -TV 45070) is the less active R-enantiomer of Funapide. Funapide is a potent inhibitor of the sodium channel Nav1.7, Nav1.8 and other Nav channels expressed in the peripheral nervous system. Fornabil is an orally effective analgesic agent[1][2].

Product Specifications

CAS Number

[1259933-15-7]

Product Name Alternative

(R) -TV 45070; (R) -XEN402

UNSPSC

12352005

Target

Sodium Channel

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel

Applications

Neuroscience-Neuromodulation

Field of Research

Inflammation/Immunology; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/r-funapide.html

Purity

99.22

Solubility

DMSO : 220 mg/mL (ultrasonic)

Smiles

O=C([C@@]12COC3=C1C=C(OCO4)C4=C3)N(CC5=CC=C(C(F)(F)F)O5)C6=C2C=CC=C6

Molecular Formula

C22H14F3NO5

Molecular Weight

429.35

References & Citations

[1]Sharan K Bagal, et al. Recent progress in sodium channel modulators for pain. Bioorg Med Chem Lett. 2014 Aug 15;24 (16) :3690-9.|[2]Kitano Y, et al. Inhibition of NaV1.7: the possibility of ideal analgesics. RSC Med Chem. 2022 Aug 1;13 (8) :895-920.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

Nav1.7; Nav1.8

Available Sizes

Curated Selection

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