ADX88178
ADX88178 is a potent metabotropic glutamate receptor 4 positive allosteric modulator (mGluR4 PAM) with an EC50 of 4 nM for human mGluR4.
Product Specifications
CAS Number
1235318-89-4
UNSPSC
12352005
Hazard Statement
H315, H319
Target
MGluR
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/ADX88178.html
Purity
99.50
Solubility
DMSO : 16.67 mg/mL (ultrasonic)
Smiles
CC1=C(C2=CNN=C2)N=C(NC3=NC=CC(C)=N3)S1
Molecular Formula
C12H12N6S
Molecular Weight
272.33
Precautions
H315, H319
References & Citations
[1]Fujinaga M, et al. Radiosynthesis and evaluation of 5-methyl-N- (4-[ (11) C]methylpyrimidin-2-yl) -4- (1H-pyrazol-4-yl) thiazol-2-amine ([ (11) C]ADX88178) as a novel radioligand for imaging of metabotropic glutamate receptor subtype 4 (mGluR4) . Bioorg Med Chem Lett. 2016 Jan 15;26 (2) :370-4.|[2]Ponnazhagan R, et al. The Metabotropic Glutamate Receptor 4 Positive Allosteric Modulator ADX88178 Inhibits Inflammatory Responses in Primary Microglia. J Neuroimmune Pharmacol. 2016 Jun;11 (2) :231-7.|[3]Kalinichev M, et al. Characterization of the novel positive allosteric modulator of the metabotropic glutamate receptor 4 ADX88178 in rodent models of neuropsychiatric disorders. J Pharmacol Exp Ther. 2014 Sep;350 (3) :495-505.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
MGluR4
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
LY418954 100 µg
SC35 (SRSF2) (NM_003016) Human Over-expression Lysate
Sign In for Pricing
View Details 
LY421490 100 µg
KRTAP27-1 (NM_001077711) Human Over-expression Lysate
Sign In for Pricing
View Details 
BNC683117-500 1x 500 µL
CD19 (B-Lymphocyte Marker) (CD19/3117), CF568 conjugate, 0.1mg/mL
Sign In for Pricing
View Details