ADX88178
ADX88178 is a potent metabotropic glutamate receptor 4 positive allosteric modulator (mGluR4 PAM) with an EC50 of 4 nM for human mGluR4.
Product Specifications
CAS Number
[1235318-89-4]
UNSPSC
12352005
Hazard Statement
H315, H319
Target
MGluR
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/ADX88178.html
Purity
99.50
Solubility
DMSO : 16.67 mg/mL (ultrasonic)
Smiles
CC1=C(C2=CNN=C2)N=C(NC3=NC=CC(C)=N3)S1
Molecular Formula
C12H12N6S
Molecular Weight
272.33
Precautions
H315, H319
References & Citations
[1]Fujinaga M, et al. Radiosynthesis and evaluation of 5-methyl-N- (4-[ (11) C]methylpyrimidin-2-yl) -4- (1H-pyrazol-4-yl) thiazol-2-amine ([ (11) C]ADX88178) as a novel radioligand for imaging of metabotropic glutamate receptor subtype 4 (mGluR4) . Bioorg Med Chem Lett. 2016 Jan 15;26 (2) :370-4.|[2]Ponnazhagan R, et al. The Metabotropic Glutamate Receptor 4 Positive Allosteric Modulator ADX88178 Inhibits Inflammatory Responses in Primary Microglia. J Neuroimmune Pharmacol. 2016 Jun;11 (2) :231-7.|[3]Kalinichev M, et al. Characterization of the novel positive allosteric modulator of the metabotropic glutamate receptor 4 ADX88178 in rodent models of neuropsychiatric disorders. J Pharmacol Exp Ther. 2014 Sep;350 (3) :495-505.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
MGluR4
Available Sizes
Curated Selection
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