AChE/BuChE-IN-4

AChE/BuChE-IN-4 (compound 4a) is aorally activeandbrain-penetrantmultitarget-directedAChE/BuChEinhibitor againstAChEandBuChE, with theIC50of 2.08 and 7.41 μM[1].

Product Specifications

CAS Number

[1997158-25-4]

UNSPSC

12352005

Target

Cholinesterase (ChE)

Type

Reference compound

Related Pathways

Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/ache-buche-in-4.html

Purity

99.66

Solubility

DMSO : ≥ 125 mg/mL

Smiles

NC1=NC=CC(NCC2CCN(CC2)CC3=CC=CC=C3)=N1

Molecular Formula

C17H23N5

Molecular Weight

297.40

References & Citations

[1]Conceição RAD, et al. Structure-based design of new N-benzyl-piperidine derivatives as multitarget-directed AChE/BuChE inhibitors for Alzheimer's disease [published online ahead of print, 2023 Oct 5]. J Cell Biochem. 2023;10.1002/jcb.30483.