NNOS-IN-1

NNOS-IN-1 (Compound 14) is an inhibitor for nitric oxide synthases (NOS), that exhibits inhibitory activities against neuroal, inducible and endothelial NOS, with IC50s of 2.5, 5.7 and 13 μM, respectively[1].

Product Specifications

CAS Number

[945762-00-5]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

NO Synthase

Type

Reference compound

Related Pathways

Immunology/Inflammation

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/nnos-in-1.html

Purity

99.53

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

N#CC1=CC=CC2=C1NN=C2Br

Molecular Formula

C8H4BrN3

Molecular Weight

222.04

Precautions

H302, H315, H319, H335

References & Citations

[1]Cottyn B, et al., Inhibitory effects of a series of 7-substituted-indazoles toward nitric oxide synthases: particular potency of 1H-indazole-7-carbonitrile. Bioorg Med Chem. 2008 Jun 1;16 (11) :5962-73.