NNOS-IN-1
NNOS-IN-1 (Compound 14) is an inhibitor for nitric oxide synthases (NOS), that exhibits inhibitory activities against neuroal, inducible and endothelial NOS, with IC50s of 2.5, 5.7 and 13 μM, respectively[1].
Product Specifications
CAS Number
[945762-00-5]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
NO Synthase
Type
Reference compound
Related Pathways
Immunology/Inflammation
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/nnos-in-1.html
Purity
99.53
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
N#CC1=CC=CC2=C1NN=C2Br
Molecular Formula
C8H4BrN3
Molecular Weight
222.04
Precautions
H302, H315, H319, H335
References & Citations
[1]Cottyn B, et al., Inhibitory effects of a series of 7-substituted-indazoles toward nitric oxide synthases: particular potency of 1H-indazole-7-carbonitrile. Bioorg Med Chem. 2008 Jun 1;16 (11) :5962-73.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
ENOS; iNOS; nNOS
Available Sizes
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