Human CCR7 Full Length Protein, His, Flag Tag (Detergent)

The monoclonal antibody mAb-729 reacts with the human CC chemokine receptor, CCR7. The protein encoded by this gene is a member of the G protein-coupled receptor family. This receptor was identified as a gene induced by the Epstein-Barr virus (EBV), and is thought to be a mediator of EBV effects on B lymphocytes. This receptor is expressed in various lymphoid tissues and activates B and T lymphocytes. It has been shown to control the migration of memory T cells to inflamed tissues, as well as stimulate dendritic cell maturation. The chemokine (C-C motif) ligand 19 (CCL19/ECL) has been reported to be a specific ligand of this receptor. Signals mediated by this receptor regulate T cell homeostasis in lymph nodes, and may also function in the activation and polarization of T cells, and in chronic inflammation pathogenesis.

Product Specifications

Background

Specifications

This protein carries a polyhistidine tag at the C-terminus, followed by a Flag tag. The protein has a calculated MW of 58.9 kDa.

Accession Number

P32248

Expression Region

Gln 25 - Pro 378

Host

HEK293

Target

CCR7

Conjugation

Unconjugated

Tag

C-10xHis & C-Flag

Source

Human

Stability

The product MUST be stored at -70°C or lower upon receipt; -70°C for 3 months under sterile conditions.

Endotoxin

1.0 EU per μg

Purity

85%

Bioactivity

Immobilized Human CCR7 Full Length Protein, His,Flag Tag (Cat. No. CC7-H52D3) at 1 μg/mL (100 μL/well) can bind Anti-CCR7 Antibody, Human IgG1 with a linear range of 0.2-8 ng/mL (QC tested).