Cryptosporioptide A
Cryptosporioptide A (Compound 3) is a pigment protein tyrosine phosphatase inhibitor derived from the insect-parasitic fungus Cordyceps gracilioides. Cryptosporioptide A inhibits PTP1B, SHP2, CDC25B, LAR and SHP1 enzymes with IC50 of 7.3, 5.7, 7.6, >50, 4.9 μg/mL, respectively[1].
Product Specifications
CAS Number
[1647101-05-0]
UNSPSC
12352005
Target
Phosphatase; SHP1
Type
Natural Products
Related Pathways
Metabolic Enzyme/Protease; Protein Tyrosine Kinase/RTK
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/cryptosporioptide-a.html
Solubility
10 mM in DMSO
Smiles
C[C@@]1([C@]23[C@](C(C4=C(O)C(C(O)=O)=CC=C4O3)=O)([H])[C@@](O)([C@@]1([H])OC(CC(N2)=O)=O)C)O
Molecular Formula
C18H17NO10
Molecular Weight
407.33
References & Citations
[1]Wei PY, et al. Three new pigment protein tyrosine phosphatases inhibitors from the insect parasite fungus Cordyceps gracilioides: terreusinone A, pinophilin C and cryptosporioptide A. Molecules. 2015 Apr 2;20 (4) :5825-34.
Shipping Conditions
Room temperature
Scientific Category
Natural Products
Clinical Information
No Development Reported
Available Sizes
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