Cryptosporioptide A

Cryptosporioptide A (Compound 3) is a pigment protein tyrosine phosphatase inhibitor derived from the insect-parasitic fungus Cordyceps gracilioides. Cryptosporioptide A inhibits PTP1B, SHP2, CDC25B, LAR and SHP1 enzymes with IC50 of 7.3, 5.7, 7.6, >50, 4.9 μg/mL, respectively[1].

Product Specifications

CAS Number

[1647101-05-0]

UNSPSC

12352005

Target

Phosphatase; SHP1

Type

Natural Products

Related Pathways

Metabolic Enzyme/Protease; Protein Tyrosine Kinase/RTK

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/cryptosporioptide-a.html

Solubility

10 mM in DMSO

Smiles

C[C@@]1([C@]23[C@](C(C4=C(O)C(C(O)=O)=CC=C4O3)=O)([H])[C@@](O)([C@@]1([H])OC(CC(N2)=O)=O)C)O

Molecular Formula

C18H17NO10

Molecular Weight

407.33

References & Citations

[1]Wei PY, et al. Three new pigment protein tyrosine phosphatases inhibitors from the insect parasite fungus Cordyceps gracilioides: terreusinone A, pinophilin C and cryptosporioptide A. Molecules. 2015 Apr 2;20 (4) :5825-34.