Mal-PEG4- (PEG3-DBCO) - (PEG3-TCO)
Mal-PEG4- (PEG3-DBCO) - (PEG3-TCO) is a cleavable 10 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) [1]. Mal-PEG4- (PEG3-DBCO) - (PEG3-TCO) is a click chemistry reagent, it contains a TCO group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing Tetrazine groups.
Product Specifications
UNSPSC
12352203
Hazard Statement
H302-H315-H319-H335
Target
ADC Linker
Type
ADC Related
Related Pathways
Antibody-drug Conjugate/ADC Related
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/mal-peg4-peg3-dbco-peg3-tco.html
Solubility
10 mM in DMSO
Smiles
O=C(CCC(NCCOCCOCCOCCN(C(CCOCCOCCOCCOCCNC(CCN1C(C=CC1=O)=O)=O)=O)CCOCCOCCOCCNC(O[C@H]2CCC/C([H])=C/CC2)=O)=O)N3CC4=C(C=CC=C4)C#CC5=C3C=CC=C5
Molecular Formula
C62H88N6O18
Molecular Weight
1205.39
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
References & Citations
[1]Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16 (5) :315-337.
Shipping Conditions
Room temperature
Scientific Category
ADC Related
Clinical Information
No Development Reported
Isoform
Cleavable Linker
Available Sizes
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