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Anti-Shank 2 Antibody

Mouse Monoclonal Antibody specific to Shank2

Product Specifications

Product Name Alternative

Shank2, Cortactin-binding protein 1, CortBP1, GKAP/SAPAP-interacting protein, Proline-rich synapse-associated protein 1, ProSAP1, SPANK-3

Gene Name

Shank2

NCBI Gene ID

<a href="https://www.ncbi.nlm.nih.gov/gene/?term=Shank2">Shank2</a>

UniProt

Q9QX74

Cellular Locus

Apical cell membrane, Cytoplasm, Cell junction, synapse, Cell junction, synapse, postsynaptic density, Cell projection, growth cone, Cell projection, dendritic spine

Host

Mouse

Reactivity

Human, Mouse (Weak), Rat

Immunogen

Fusion protein corresponding to aa 84-309 (SH3/PDZ domains) of rat Shank2 (accession no. Q9QX74). This sequence is 94

Target Antigen

SH3 and multiple ankyrin repeat domains protein 2

Target

Shank 2

Clonality

Monoclonal

Isotype

IgG1

Type

Antibody

Applications

WB, IHC, IP, ICC/IF, AM

Field of Research

Neuroscience

Purification Method

Purified by Protein G affinity chromatography

Concentration

Lot Specific

Dilution

Dilute in PBS or medium that is identical to that used in the assay system.

Format

Purified

Form

Liquid

Buffer

Phosphate Buffered Saline

Function

Seems to be an adapter protein in the postsynaptic density (PSD) of excitatory synapses that interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors, and the actin-based cytoskeleton. May play a role in the structural and functional organization of the dendritic spine and synaptic junction. {PubMed:10506216}.

Additionnal Information

Immunoblotting: use at 1-10ug/ml. A band of ~160kDa is detected. <br><br>Immunohistochemistry and <br><br>Immunocytochemistry: use at 0.1-1ug/ml <br><br>Immunofluorescence: use at 1-10ug/ml <br><br>These are recommended concentrations. User should determine optimal concentrations for their application. <br><br>Positive control: Adult rat brain lysate.

Storage Conditions

This antibody is stable for at least one (1) year at -20°C.

Product Datasheet

https://www.qedbio.com/wp-content/uploads/pdf/56466.pdf

Specificity

This antibody recognizes human, mouse (weak), and rat Shank2. It does not cross- react with Shank1 or Shank3.

Formulation

PBS, pH 7.4; 50% glycerol, 0.09% sodium azide.

Buffer pH

pH 7.4

Target Background

Shank proteins are a family of scaffold proteins identified through their interaction with a variety of membrane and cyto- plasmic proteins. Shank proteins at postsynaptic sites of excitatory synapses play roles in signal transmission into the postsynaptic neuron. Shank proteins are crucial in receptor tyrosine kinase signaling. Shank2 is expressed in neurons of the developing retina and could play a role in neuronal differentiation of the developing retina. Recent studies suggest that disruption of glutamate receptors at the Shank-postsynaptic platform could contribute to the destruction of post-synaptic density which underlies synaptic dysfunction and loss in Alzheimer's disease.

CAS Number

9007-83-4

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