CRANAD-2

CRANAD-2 is a near-infrared (NIR) Aβ plaque-specific fluorescent probe. CRANAD 2 penetrates the blood brain barrier and has a high affinity for Aβ aggregates with a Kd of 38 nM[1][2].

Product Specifications

CAS Number

[1193447-34-5]

UNSPSC

12352005

Hazard Statement

H315, H319

Target

Amyloid-β

Type

Reference compound

Related Pathways

Neuronal Signaling

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/cranad-2.html

Purity

98.0

Solubility

DMF : 2 mg/mL (ultrasonic; warming; heat to 60°C) |DMSO : 2.08 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

CN(C)C(C=C1)=CC=C1/C=C/C2=O[B+3]([F-])([F-])O=C(/C=C/C3=CC=C(N(C)C)C=C3)[CH-]2

Molecular Formula

C23H25BF2N2O2

Molecular Weight

410.26

Precautions

H315, H319

References & Citations

[1]Ran C, et al. Design, synthesis, and testing of difluoroboron-derivatized curcumins as near-infrared probes for in vivo detection of amyloid-beta deposits. J Am Chem Soc. 2009 Oct 28;131 (42) :15257-61. |[2]Ran C, et al. Non-conjugated small molecule FRET for differentiating monomers from higher molecular weight amyloid beta species. PLoS One. 2011 Apr 29;6 (4) :e19362.