A-674563
A-674563 is an orally active Akt1 inhibitor with a Ki of 11 nM.
Product Specifications
CAS Number
552325-73-2
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Akt
Type
Reference compound
Related Pathways
PI3K/Akt/mTOR
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/a-674563.html
Purity
99.87
Solubility
DMSO : 83.33 mg/mL (ultrasonic)
Smiles
N[C@@H](CC1=CC=CC=C1)COC2=CC(C3=CC4=C(C=C3)NN=C4C)=CN=C2
Molecular Formula
C22H22N4O
Molecular Weight
358.44
Precautions
H302, H315, H319, H335
References & Citations
[1]Luo Y, et al. Potent and selective inhibitors of Akt kinases slow the progress of tumors in vivo. Mol Cancer Ther, 2005, 4 (6), 977-986.|[2]Zhu QS, et al. Soft tissue sarcoma cells are highly sensitive to AKT blockade: a role for p53-independent up-regulation of GADD45 alpha. Cancer Res, 2008, 68 (8), 2895-2903.|[3]Zou Y, et al. Pre-clinical assessment of A-674563 as an anti-melanoma agent. Biochem Biophys Res Commun. 2016 Aug 12;477 (1) :1-8.|[4]Xu L, et al. Concurrent targeting Akt and sphingosine kinase 1 by A-674563 in acute myeloid leukemia cells. Biochem Biophys Res Commun. 2016 Apr 15;472 (4) :662-8.|[5]Wang A, et al. Dual inhibition of AKT/FLT3-ITD by A674563 overcomes FLT3 ligand-induced drug resistance in FLT3-ITD positive AML. Oncotarget. 2016 May 17;7 (20) :29131-42.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Akt1
Citation 01
Cell Commun Signal. 2025 Apr 23;23 (1) :194.|Cell Signal. 2023 Sep:109:110753.|J Proteome Res. 2018 Oct 5;17 (10) :3360-3369.|Oncotarget. 2016 May 17;7 (20) :29131-42. |Aging. 2020 Nov 17;12 (22) :23114-23128.
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