Talatisamine

Talatisamine, a aconitum alkaloid, is specific K+ channel blocker. Talatisamine attenuates beta-amyloid oligomers induced neurotoxicity in cultured cortical neurons[1].

Product Specifications

CAS Number

[20501-56-8]

UNSPSC

12352005

Target

Potassium Channel

Type

Natural Products

Related Pathways

Membrane Transporter/Ion Channel

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/talatisamine.html

Concentration

10mM

Purity

99.77

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

CO[C@@H]1C(C(N(CC)C2)C3C4)([C@@](C[C@@]5([H])[C@@H]6O)([H])[C@@]6([H])[C@@]3(C[C@@H]5OC)O)[C@@]4([H])[C@@]2(COC)CC1

Molecular Formula

C24H39NO5

Molecular Weight

421.57

References & Citations

[1]Wang Y, et al. The newly identified K+ channel blocker talatisamine attenuates beta-amyloid oligomers induced neurotoxicity in cultured cortical neurons. Neurosci Lett. 2012 Jun 19;518 (2) :122-7.