N-Formyl-Met-Leu-Phe-Lys

N-Formyl-Met-Leu-Phe-Lys (fMLFK) is a peptide, acts as a potent and selective agonist of FPR1, with EC50s of 3.5 nM, 6.7 μM and 0.88 μM for FPR1, FPR2 and FPR2-D2817.32G, respectively[1].

Product Specifications

CAS Number

[67247-11-4]

Product Name Alternative

FMLFK

UNSPSC

12352209

Target

Formyl Peptide Receptor (FPR)

Type

Peptides

Related Pathways

GPCR/G Protein

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/n-formyl-met-leu-phe-lys.html

Purity

99.83

Solubility

DMSO : 22.22 mg/mL (ultrasonic; adjust pH to 3 with 1M HCl)

Smiles

NCCCC[C@@H](C(O)=O)NC([C@H](CC1=CC=CC=C1)NC([C@H](CC(C)C)NC([C@H](CCSC)NC=O)=O)=O)=O

Molecular Formula

C27H43N5O6S

Molecular Weight

565.73

References & Citations

[1]He HQ, et al. Structural determinants for the interaction of formyl peptide receptor 2 with peptide ligands. J Biol Chem. 2014 Jan 24;289 (4) :2295-306.