mTOR inhibitor-8
Product Specifications
UNSPSC Description
mTOR inhibitor-8 is an mTOR inhibitor and autophagy inducer. mTOR inhibitor-8 inhibits the activity of mTOR via FKBP12 and induces autophagy of A549 human lung cancer cells[1].
Target Antigen
Autophagy; mTOR
Type
Reference compound
Related Pathways
Autophagy;PI3K/Akt/mTOR
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/mtor-inhibitor-8.html
Purity
98.14
Solubility
DMSO : 25 mg/mL (ultrasonic)
Smiles
COC1=CC=C(C2CC(C3=CC=C(Cl)C=C3)=NN2C4=NC(C5=CC=NC=C5)=CS4)C=C1
Molecular Weight
446.95
References & Citations
[1]ZhaoMin Lin, et al. Discovery of new fluorescent thiazole-pyrazoline derivatives as autophagy inducers by inhibiting mTOR activity in A549 human lung cancer cells. Cell Death Dis. 2020 Jul 20;11(7):551.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-131344/mTOR-inhibitor-8-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-131344/mTOR-inhibitor-8-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
2489196-70-3
Available Sizes
Curated Selection
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