MTOR inhibitor-8
MTOR inhibitor-8 is an mTOR inhibitor and autophagy inducer. mTOR inhibitor-8 inhibits the activity of mTOR via FKBP12 and induces autophagy of A549 human lung cancer cells[1].
Product Specifications
CAS Number
[2489196-70-3]
UNSPSC
12352005
Target
Autophagy; mTOR
Type
Reference compound
Related Pathways
Autophagy; PI3K/Akt/mTOR
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/mtor-inhibitor-8.html
Purity
98.14
Solubility
DMSO : 31.25 mg/mL (ultrasonic)
Smiles
COC1=CC=C(C2CC(C3=CC=C(Cl)C=C3)=NN2C4=NC(C5=CC=NC=C5)=CS4)C=C1
Molecular Formula
C24H19ClN4OS
Molecular Weight
446.95
References & Citations
[1]ZhaoMin Lin, et al. Discovery of new fluorescent thiazole-pyrazoline derivatives as autophagy inducers by inhibiting mTOR activity in A549 human lung cancer cells. Cell Death Dis. 2020 Jul 20;11 (7) :551.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
MTOR
Available Sizes
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
![Mouse Monoclonal CD63 Antibody (H5C6) [PE/Atto594]](https://cdn.genprice.uk/genprice/uk/genprice4.webp)
RC229683L3V 200 µL
C1orf49 (TEX35) (NM_001170724) Human Tagged ORF Clone Lentiviral Particle
Ask
View Details ![Mouse Monoclonal Vinculin Antibody (VCL/2573) [PE]](https://cdn.genprice.uk/genprice/uk/genprice2.webp)
MBS6391410-01 0.1 mL
PTPN5 (STEP, Tyrosine-protein Phosphatase Non-receptor Type 5, Striatum-enriched Protein-tyrosine Phosphatase, Neural-specific Protein-tyrosine Phosphatase, FLJ14427) (FITC)
Ask
View Details MBS6391410-02 5x 0.1 mL
PTPN5 (STEP, Tyrosine-protein Phosphatase Non-receptor Type 5, Striatum-enriched Protein-tyrosine Phosphatase, Neural-specific Protein-tyrosine Phosphatase, FLJ14427) (FITC)
Ask
View Details