Hinokitiol
Hinokitiol is a component of essential oils isolated from Chymacyparis obtusa, reduces Nrf2 expression, and decreases DNMT1 and UHRF1 mRNA and protein expression, with anti-infective, anti-oxidative, and anti-tumor activities.
Product Specifications
CAS Number
[499-44-5]
Product Name Alternative
β-Thujaplicin
UNSPSC
12352005
Hazard Statement
H302
Target
DNA Methyltransferase; Keap1-Nrf2; Virus Protease
Type
Natural Products
Related Pathways
Anti-infection; Epigenetics; NF-κB
Applications
Cancer-programmed cell death
Field of Research
Cancer; Infection
Assay Protocol
https://www.medchemexpress.com/Hinokitiol.html
Concentration
10mM
Purity
99.83
Solubility
DMSO : 100 mg/mL (ultrasonic) |H2O : < 0.1 mg/mL
Smiles
O=C1C(O)=CC(C(C)C)=CC=C1
Molecular Formula
C10H12O2
Molecular Weight
164.20
Precautions
H302
References & Citations
[1]Ouyang WC, et al. Hinokitiol suppresses cancer stemness and oncogenicity in glioma stem cells by Nrf2 regulation. Cancer Chemother Pharmacol. 2017 Aug;80 (2) :411-419.|[2]Seo JS, et al. Hinokitiol induces DNA demethylation via DNMT1 and UHRF1 inhibition in colon cancer cells. BMC Cell Biol. 2017 Feb 27;18 (1) :14.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
DNMT1
Available Sizes
Curated Selection
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