3-Methylglutaconic acid

3-Methylglutaconic acid is the major metabolites accumulating in 3-Methylglutaconic aciduria (MGTA) . 3-Methylglutaconic acid can induce lipid oxidative damage and protein oxidative. 3-Methylglutaconic acid decreases the non-enzymatic antioxidant defenses in cerebral cortex supernatants to elicit oxidative stress in the cerebral cortex. 3-Methylglutaconic acid can be used for brain damage disease research[1].

Product Specifications

CAS Number

[5746-90-7]

Product Name Alternative

β-Methylglutaconic acid

UNSPSC

12352211

Hazard Statement

H302, H315, H319, H335

Target

Endogenous Metabolite; GABA Receptor

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; Neuronal Signaling

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Metabolic Disease; Neurological Disease; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/3-methylglutaconic-acid.html

Purity

99.60

Solubility

DMSO : 250 mg/mL (ultrasonic)

Smiles

O=C(/C=C(CC(O)=O)\C)O

Molecular Formula

C6H8O4

Molecular Weight

144.13

Precautions

H302, H315, H319, H335

References & Citations

[1]Guilhian Leipnitz, et al. Induction of oxidative stress by the metabolites accumulating in 3-methylglutaconic aciduria in cerebral cortex of young rats. Life Sci. 2008 Mar 12;82 (11-12) :652-62. |[2]N L Alsip, et al. Cardiovascular effects of 3-mercaptopropionic acid and levels of GABA in regions of the brain of guinea-pigs. Neuropharmacology. 1984 Mar;23 (3) :349-57.|[3] E Girardi, et al. 3-mercaptopropionic acid-induced seizures decrease NR2B expression in Purkinje cells: cyclopentyladenosine effect. Cell Mol Neurobiol. 2010 Oct;30 (7) :985-90.|[4]Leipnitz G, et al. Induction of oxidative stress by the metabolites accumulating in 3-methylglutaconic aciduria in cerebral cortex of young rats. Life Sci. 2008 Mar 12;82 (11-12) :652-62.