SRX3177
Product Specifications
UNSPSC Description
SRX3177 is a triple inhibitor of CDK4/6, PI3K, and BRD4, with IC50s of 33 nM (BRD4 BD1), 89 nM (BRD4 BD2), 79 nM (PI3Kα), 83 nM (PI3Kδ), 3.18 μM (PI3Kγ), [1].
Target Antigen
CDK; Epigenetic Reader Domain; PI3K
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage;Epigenetics;PI3K/Akt/mTOR
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/srx3177.html
Solubility
DMSO : 25 mg/mL (ultrasonic)
Smiles
O=C1C=C(N2CCOCC2)OC3=C1SC=C3C4=CC=C(NC5=NC6=C(C=C(N6C7CCCC7)C(N(C)C)=O)C=N5)C=C4
Molecular Weight
584.69
References & Citations
[1]Burgoyne AM, et al. A triple action CDK4/6-PI3K-BET inhibitor with augmented cancer cell cytotoxicity. Cell Discov. 2020 Jul 28;6(1):49.
Shipping Conditions
Room Temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-153894/SRX3177-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-153894/SRX3177-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
2241237-51-2
Available Sizes
Curated Selection
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