Alpha-Mangostin (Standard)

Alpha-Mangostin (Standard) is the analytical standard of alpha-Mangostin. This product is intended for research and analytical applications. alpha-Mangostin (α-Mangostin) is a dietary xanthone with broad biological activities, such as antioxidant, anti-allergic, antiviral, antibacterial, anti-inflammatory and anticancer effects. It is an inhibitor of mutant IDH1 (IDH1-R132H) with a Ki of 2.85 μM.

Product Specifications

CAS Number

[6147-11-1]

Product Name Alternative

α-Mangostin (Standard)

UNSPSC

12352005

Hazard Statement

H301

Target

Apoptosis; Bacterial; Fungal; Reactive Oxygen Species (ROS) ; Reference Standards; Virus Protease

Type

Reference Standards

Related Pathways

Anti-infection; Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB; Others

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/alpha-mangostin-standard.html

Purity

99.44

Solubility

10 mM in DMSO

Smiles

O=C1C2=C(OC3=C1C(C/C=C(C)\C)=C(OC)C(O)=C3)C=C(O)C(C/C=C(C)\C)=C2O

Molecular Formula

C24H26O6

Molecular Weight

410.46

Precautions

H301

References & Citations

[1]Kim HJ, et al. Discovery of α-mangostin as a novel competitive inhibitor against mutant isocitrate dehydrogenase-1. Bioorg Med Chem Lett. 2015 Dec 1;25 (23) :5625-31.|[2]Lee HN, et al. Antitumor and apoptosis-inducing effects of α-mangostin extracted from the pericarp of the mangosteen fruit (Garcinia mangostana L.) in YD-15 tongue mucoepidermoid carcinoma cells. Int J Mol Med. 2016 Apr;37 (4) :939-48.