Nervonic acid

Nervonic acid is a monounsaturated fatty acid with oral activity. Nervonic acid exerts anti-inflammatory activity by inhibiting NF-κB signaling. Nervonic acid can be used in the study of neurodegenerative diseases[1][2][3].

Product Specifications

CAS Number

[506-37-6]

Product Name Alternative

Selacholeic acid; cis-15-Tetracosenoic acid

UNSPSC

12352211

Hazard Statement

H302, H315, H319, H335

Target

Endogenous Metabolite; NF-κB

Type

Natural Products

Related Pathways

Metabolic Enzyme/Protease; NF-κB

Applications

Neuroscience-Neuromodulation

Field of Research

Inflammation/Immunology; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/Nevonic_acid.html

Concentration

10mM

Purity

99.95

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

CCCCCCCC/C=C\CCCCCCCCCCCCCC(O)=O

Molecular Formula

C24H46O2

Molecular Weight

366.62

Precautions

H302, H315, H319, H335

References & Citations

[1]Umemoto H, et al. Protective Effect of Nervonic Acid Against 6-Hydroxydopamine-Induced Oxidative Stress in PC-12 Cells. J Oleo Sci. 2021;70 (1) :95-102.|[2]Hu D, et al. Nervonic acid amends motor disorder in a mouse model of Parkinson's disease. Transl Neurosci. 2022 Apr 20;13 (1) :71.|[3]Yuan SN, et al. Improved colonic inflammation by nervonic acid via inhibition of NF-κB signaling pathway of DSS-induced colitis mice. Phytomedicine. 2023 Apr;112:154702.