Lobelane (hydrochloride)
Product Specifications
UNSPSC Description
Lobelane hydrochloride is a biologically active compound that has the activity of inhibiting vesicular monoamine transporter-2 (VMAT2). Lobelane hydrochloride has a low affinity for nicotinic acetylcholine receptors (nAChR), thereby enhancing its selectivity for VMAT2. Synthetic structural changes of lobelane hydrochloride have led to some related analogs that show mild changes in affinity for VMAT2. The most potent synthetic lobelane hydrochloride obtained after structural modification has a K(i) value of 630 nM, showing significant VMAT2 selectivity. The biological activity of lobelane hydrochloride suggests that it has the potential to be used in the development of compounds to inhibit methamphetamine abuse[1].
Target Antigen
Histone Methyltransferase
Type
Reference compound
Related Pathways
Epigenetics
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/lobelane-hydrochloride.html
Smiles
CN([C@@H](CCC1)CCC2=CC=CC=C2)[C@H]1CCC3=CC=CC=C3.Cl
Molecular Weight
343.93
References & Citations
[1]Defunctionalized lobeline analogues: structure-activity of novel ligands for the vesicular monoamine transporter
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-118990/Lobelane-hydrochloride-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-118990/
Clinical Information
No Development Reported
CAS Number
246244-19-9
Curated Selection
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