SAR-260301
SAR-260301 is an orally available and selective PI3Kβ inhibitor with an IC50 of 23 nM[1][2].
Product Specifications
CAS Number
[1260612-13-2]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
PI3K
Type
Reference compound
Related Pathways
PI3K/Akt/mTOR
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/SAR-260301.html
Purity
99.95
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C1N=C(CC(N2[C@@H](C)CC3=C2C=CC=C3)=O)NC(N4CCOCC4)=C1
Molecular Formula
C19H22N4O3
Molecular Weight
354.40
Precautions
H302, H315, H319, H335
References & Citations
[1]Certal V, et al. Discovery and optimization of pyrimidone indoline amide PI3Kβ inhibitors for the treatment of phosphatase and tensin homologue (PTEN) -deficient cancers. J Med Chem. 2014 Feb 13;57 (3) :903-20.|[2]Bonnevaux H, et al. Concomitant Inhibition of PI3Kβ and BRAF or MEK in PTEN-Deficient/BRAF-Mutant Melanoma Treatment: Preclinical Assessment of SAR260301 Oral PI3Kβ-Selective Inhibitor. Mol Cancer Ther. 2016 Jul;15 (7) :1460-71.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 1
Isoform
PI3KC2γ; PI3Kα; PI3Kβ; PI3Kγ; PI3Kδ; Vps34
Available Sizes
Curated Selection
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