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Lunarine

Lunarine is an alkaloid, which can be isolated from the seeds of kale (Lunaria annua) . Lunarine lowers the blood pressure, stimulates small intestinal motility, inhibits spontaneous contractions of uterus and nervous system, and exhibits an acute toxicity with LD50 of 62.3 mg/kg in dogs and rabbits. Lunarine exhibits antiparasitic activity through a competitive inhibition of protozoan oxidoreductase trypanothione reductase (TryR) with Ki of 304 μM[1].

Product Specifications

CAS Number

24185-51-1

UNSPSC

12352005

Target

Parasite

Type

Natural Products

Related Pathways

Anti-infection

Applications

COVID-19-immunoregulation

Field of Research

Infection; Neurological Disease; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/lunarine.html

Smiles

O=C1C[C@]2([H])[C@]3(CC1)C4=CC(/C=C/C(NCCCNCCCCNC(/C=C/3)=O)=O)=CC=C4O2

Molecular Formula

C25H31N3O4

Molecular Weight

437.53

References & Citations

[1]Hamilton CJ, et al., Time-dependent inhibitors of trypanothione reductase: analogues of the spermidine alkaloid lunarine and related natural products. Bioorg Med Chem. 2006 Apr 1;14 (7) :2266-78.|[2]HENDERSON FG, et al., The pharmacology of lunarine, the alkaloid of Lunaria biennis. J Am Pharm Assoc Am Pharm Assoc. 1950 Sep;39 (9) :516-9.

Shipping Conditions

Room temperature

Scientific Category

Natural Products

Clinical Information

No Development Reported

Frequently Asked Questions

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