Lunarine
Product Specifications
UNSPSC Description
Lunarine is an alkaloid, which can be isolated from the seeds of kale (Lunaria annua). Lunarine lowers the blood pressure, stimulates small intestinal motility, inhibits spontaneous contractions of uterus and nervous system, and exhibits an acute toxicity with LD50 of 62.3 mg/kg in dogs and rabbits. Lunarine exhibits antiparasitic activity through a competitive inhibition of protozoan oxidoreductase trypanothione reductase (TryR) with Ki of 304 μM[1].
Target Antigen
Parasite
Type
Natural Products
Related Pathways
Anti-infection
Applications
COVID-19-immunoregulation
Field of Research
Infection; Neurological Disease; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/lunarine.html
Smiles
O=C1C[C@]2([H])[C@]3(CC1)C4=CC(/C=C/C(NCCCNCCCCNC(/C=C/3)=O)=O)=CC=C4O2
Molecular Weight
437.53
References & Citations
[1]Hamilton CJ, et al., Time-dependent inhibitors of trypanothione reductase: analogues of the spermidine alkaloid lunarine and related natural products. Bioorg Med Chem. 2006 Apr 1;14(7):2266-78.|[2]HENDERSON FG, et al., The pharmacology of lunarine, the alkaloid of Lunaria biennis. J Am Pharm Assoc Am Pharm Assoc. 1950 Sep;39(9):516-9.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-129278/Lunarine-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-129278/
Clinical Information
No Development Reported
CAS Number
24185-51-1
Curated Selection
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