JP-2-249
JP-2-249 is a molecular glue that acts as a potent degrader of SMARCA2. JP-2-249 shows decreasing protein level of SMARCA2 in MV-4-11 cells at 1-10 μM[1].
Product Specifications
CAS Number
3036530-41-0
UNSPSC
12352005
Target
Epigenetic Reader Domain; Molecular Glues
Type
Reference compound
Related Pathways
Epigenetics; PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/jp-2-249.html
Smiles
COC1=CC=C(C(/C=C/C(N2CCN(C3=C(N)N=NC(C4=CC=CC=C4O)=C3)CC2)=O)=O)C=C1
Molecular Formula
C25H25N5O4
Molecular Weight
459.50
References & Citations
[1]Ethan S Toriki, et al. Rational Chemical Design of Molecular Glue Degraders. ACS Cent Sci. 2023 Apr 11;9 (5) :915-926.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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