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JP-2-249

JP-2-249 is a molecular glue that acts as a potent degrader of SMARCA2. JP-2-249 shows decreasing protein level of SMARCA2 in MV-4-11 cells at 1-10 μM[1].

Product Specifications

CAS Number

3036530-41-0

UNSPSC

12352005

Target

Epigenetic Reader Domain; Molecular Glues

Type

Reference compound

Related Pathways

Epigenetics; PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/jp-2-249.html

Smiles

COC1=CC=C(C(/C=C/C(N2CCN(C3=C(N)N=NC(C4=CC=CC=C4O)=C3)CC2)=O)=O)C=C1

Molecular Formula

C25H25N5O4

Molecular Weight

459.50

References & Citations

[1]Ethan S Toriki, et al. Rational Chemical Design of Molecular Glue Degraders. ACS Cent Sci. 2023 Apr 11;9 (5) :915-926.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Frequently Asked Questions

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