MEN 11270

MEN 11270, a cyclic decapeptide, is a B2 kinin receptor antagonist. MEN 11270 bound with high-affinity to the B2 kinin receptor constitutively expressed by WI38 human fibroblasts, inhibiting 3H-bradykinin (BK) with a pKi value of 10.3[1].

Product Specifications

CAS Number

[235082-52-7]

UNSPSC

12352209

Target

Bradykinin Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/men-11270.html

Purity

99.15

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C([C@]1([H])N(C([C@H]2NC([C@@H](NC(CNC([C@H](C[C@H]3O)N(C3)C([C@H](CCC4)N4C([C@H](CCCNC(N)=N)NC([C@H](N)CCCNC(N)=N)=O)=O)=O)=O)=O)CC5=CC=CS5)=O)=O)CC6=CC=CC=C6C1)N7[C@](CCCC8)([H])[C@]8([H])C[C@@]7([H])C(N[C@H](C(NCC2)=O)CCCNC(N)=N)=O

Molecular Formula

C60H90N20O11S

Molecular Weight

1299.55

References & Citations

[1]Meini S, et, al. MEN 11270, A novel selective constrained peptide antagonist with high affinity at the human B2 kinin receptor. J Pharmacol Exp Ther. 1999 Jun;289 (3) :1250-6.