Polfurmetinib
Polfurmetinib (MEK-IN-6) (Example 69) is a MEK inhibitor. MEK-IN-6 inhibits ERK1/2 (Thr202/Tyr204) phosphorylation in A375 cells (IC50: 2 nM) . Polfurmetinib can be used for research of cancer[1].
Product Specifications
CAS Number
[2845151-86-0]
Product Name Alternative
MEK-IN-6
UNSPSC
12352005
Target
ERK; MEK
Type
Reference compound
Related Pathways
MAPK/ERK Pathway; Stem Cell/Wnt
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/mek-in-6.html
Concentration
10mM
Purity
98.69
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C1C=C2C(C(N(CC2)OCCO)=O)=C(N1C)NC3=CC=C(C=C3F)SC
Molecular Formula
C18H20FN3O4S
Molecular Weight
393.43
References & Citations
[1]Shelley Allen, et al. 3,4-dihydro-2,7-naphthyridine-1,6 (2h,7h) -diones as mek inhibitors. Patent. WO2022208391.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
MEK
Available Sizes
Curated Selection
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