Guanfu base G
Guanfu base G is an antiarrhythmic alkaloid isolated from Aconitum coreanum. Guanfu base G inhibits HERG channel current with an IC50 of 17.9 μM[1][2].
Product Specifications
CAS Number
78969-72-9
UNSPSC
12352005
Target
Potassium Channel
Type
Natural Products
Related Pathways
Membrane Transporter/Ion Channel
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/guanfu-base-g.html
Purity
99.91
Solubility
10 mM in DMSO
Smiles
CC(O[C@H]([C@]1([H])[C@H]2OC(C)=O)[C@@]3([H])[C@@]45C6[C@]2(O)C3(CC1=C)C[C@@]7([H])[C@]4([H])[C@@](C)(C[C@H](OC(C)=O)C5)C[N@]67)=O
Molecular Formula
C26H33NO7
Molecular Weight
471.54
References & Citations
[1]Zhang L, et al. Simultaneous determination of Guanfu base G and its active metabolites by UPLC-MS/MS in rat plasma and its application to a pharmacokinetic study. J Chromatogr B Analyt Technol Biomed Life Sci. 2014 Apr 15;957:1-6.|[2]Huang X, et al. Comparative effects of Guanfu base A and Guanfu base G on HERG K+ channel. J Cardiovasc Pharmacol. 2012 Jan;59 (1) :77-83.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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