Guanfu base G

Guanfu base G is an antiarrhythmic alkaloid isolated from Aconitum coreanum. Guanfu base G inhibits HERG channel current with an IC50 of 17.9 μM[1][2].

Product Specifications

CAS Number

[78969-72-9]

UNSPSC

12352005

Target

Potassium Channel

Type

Natural Products

Related Pathways

Membrane Transporter/Ion Channel

Applications

Neuroscience-Neuromodulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/guanfu-base-g.html

Purity

99.91

Solubility

10 mM in DMSO

Smiles

CC(O[C@H]([C@]1([H])[C@H]2OC(C)=O)[C@@]3([H])[C@@]45C6[C@]2(O)C3(CC1=C)C[C@@]7([H])[C@]4([H])[C@@](C)(C[C@H](OC(C)=O)C5)C[N@]67)=O

Molecular Formula

C26H33NO7

Molecular Weight

471.54

References & Citations

[1]Zhang L, et al. Simultaneous determination of Guanfu base G and its active metabolites by UPLC-MS/MS in rat plasma and its application to a pharmacokinetic study. J Chromatogr B Analyt Technol Biomed Life Sci. 2014 Apr 15;957:1-6.|[2]Huang X, et al. Comparative effects of Guanfu base A and Guanfu base G on HERG K+ channel. J Cardiovasc Pharmacol. 2012 Jan;59 (1) :77-83.