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Apocynin (Standard)

Apocynin (Standard) is the analytical standard of Apocynin. This product is intended for research and analytical applications. Apocynin is a selective NADPH-oxidase inhibitor with an IC50 of 10 μM[1][2]. Apocynin improves acute lung inflammation in Carrageenan -induced pleurisy mice model[3]. Apocynin can also be used for cancer research[4]. Apocynin reverses the aging process in mesenchymal stem cells to promote osteogenesis and increases bone mass[5].

Product Specifications

CAS Number

498-02-2

Product Name Alternative

Acetovanillone (Standard)

UNSPSC

12352005

Target

NADPH Oxidase; Reference Standards

Type

Reference Standards

Related Pathways

Metabolic Enzyme/Protease; Others

Field of Research

Metabolic Disease; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/apocynin-standard.html

Smiles

CC(C1=CC=C(O)C(OC)=C1)=O

Molecular Formula

C9H10O3

Molecular Weight

166.17

References & Citations

[1]Stolk J, et al. Am J Respir Cell Mol Biol, 1994, 11 (1), 95-102.|[2]Stefanska J, et al. Mediators Inflamm, 2008, 106507.|[3]Sun J, et.al. Apocynin suppression of NADPH oxidase reverses the aging process in mesenchymal stem cells to promote osteogenesis and increase bone mass. Sci Rep. 2015 Dec 21;5:18572. |[4]Yamasaki M, et.al. Selective inhibition by apocynin of the proliferation and adhesion to fibronectin of v-H-ras-transformed 3Y1 cells. Biosci Biotechnol Biochem. 2012;76 (6) :1177-81. |[5]Impellizzeri D et al. Effect of apocynin, a NADPH oxidase inhibitor, on acute lung inflammation. Biochem Pharmacol. 2011 Mar 1;81 (5) :636-48.

Shipping Conditions

Room temperature

Scientific Category

Reference Standards

Available Sizes

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