1,1-Dimethylethyl 4- (4-amino-3-pyridinyl) -1-piperazinecarboxylate

1,1-Dimethylethyl 4- (4-amino-3-pyridinyl) -1-piperazinecarboxylate is the impurity of Palbociclib (HY-50767) . Palbociclib is an orally active selective CDK4 and CDK6 inhibitor with IC50 values of 11 and 16 nM, respectively[1].

Product Specifications

CAS Number

[1023594-50-4]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

CDK

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage

Applications

Neuroscience-Neuromodulation

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/1-1-dimethylethyl-4-4-amino-3-pyridinyl-1-piperazinecarboxylate.html

Purity

99.92

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(N1CCN(C2=C(N)C=CN=C2)CC1)OC(C)(C)C

Molecular Formula

C14H22N4O2

Molecular Weight

278.36

Precautions

H302, H315, H319, H335

References & Citations

[1]Fry DW, et al. Specific inhibition of cyclin-dependent kinase 4/6 by PD 0332991 and associated antitumor activity in human tumor xenografts. Mol Cancer Ther. 2004 Nov;3 (11) :1427-38.