hCYP1B1-IN-2
Product Specifications
UNSPSC Description
hCYP1B1-IN-2 (compound 3n) is a potent human cytochrome P450 1B1 enzyme hCYP1B1 inhibitor. hCYP1B1-IN-2 shows the extremely potent anti-hCYP1B1 activity (IC50=0.040 nM) and blocks AhR transcription activity. hCYP1B1-IN-2 potently inhibits hCYP1B1 via a mix inhibition manner, showing a Ki value of 21.71 pM[1].
Target Antigen
Aryl Hydrocarbon Receptor; Cytochrome P450
Type
Reference compound
Related Pathways
Immunology/Inflammation;Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/hcyp1b1-in-2.html
Smiles
O=C(N(CC1=CN=CN=C1)C2=O)C3=CC=C(Br)C4=CC=CC2=C43
Molecular Weight
368.18
References & Citations
[1]Wei Y, et al. Design, synthesis and structure-activity relationship of 1,8-naphthalimide derivatives as highly potent hCYP1B1 inhibitors. Bioorg Med Chem Lett. 2024 Jul 15;107:129776.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-161649/hCYP1B1-IN-2-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-161649/
Clinical Information
No Development Reported
CAS Number
3043683-33-3
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